Human aromatase (CYP19A1) is an important enzyme, which produces estrogen from androgen for maintaining the female\nreproductive function and pregnancy. Triclocarban and triclosan are antimicrobial chemicals added to personal care, household,\nand industrial products. They could be endocrine disruptors and may disrupt human CYP19A1 activity. In the present study,\nwe investigated the effects of triclocarban and triclosan on estradiol production and human CYP19A1 activity in JEG-3 cells.\nTriclocarban and triclosan reduced estradiol production in JEG-3 cells. Triclocarban and triclosan inhibited human CYP19A1 with\nIC50 values of 15.81 and 6.26
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